I Love My Kidney.org
  • Home
  • Patients
    • A Note to Patients
    • Basics>
      • Kidney Anatomy>
        • Parts of the Kidney
        • What Our Kidneys Do
        • How Our Kidneys Work
      • Patient Stories>
        • Living With Kidney Cancer
      • Treatment Options>
        • Active Surveillance
        • Considering Surgery
        • Guidelines for Surgery
        • Types of Surgery
        • Types of Kidney Surgery
        • Non-Surgical Options
      • Stages of Kidney Cancer
      • Understanding Cancer
    • Advanced>
      • Key Biomarkers>
        • Tumor Growth Rate
        • Glomerular Filtration Rate
        • Albumin / Creatinine Ratio
        • Other Key Biomarkers
      • Kidney Cancer>
        • Advanced Renal Cancer
        • Chronic Kidney Disease
        • Diagnosing Kidney Cancer
        • Risk of Metastasis
        • Types of Kidney Cancer
      • Partial Nephrectomy>
        • Partial Nephrectomy FAQ
        • Partial Nephrectomy vs Radical Nephrectomy
        • Partial Nephrectomy vs Ablation Therapy
      • Types of Kidney Surgery>
        • Kidney Surgery Videos
        • Radical Nephrectomy
        • Partial Nephrectomy
        • Cryo-Ablation Therapy
        • RF Thermal Ablation
        • HIFU Ultrasound
        • Microwave Ablation
        • Laser Ablation
    • Latest News & Info>
      • Cancer Compass
      • Cancer Survivors Network
      • MD Junction
      • Oncology Nurse Advisor
      • Topix
  • Surgeons
    • Active Surveillance
    • Biomarkers>
      • Albumin / Creatinine Ratio
      • Glomerular Filtration Rate
      • Tumor Growth Rate
      • Other Key Biomarkers
    • Clinical Calculators>
      • Glomerular Filtration Rate
      • RENAL Nephrometry Score
    • Clinical White Papers
    • Drug Therapy
    • Epidemiology
    • Guidelines>
      • American Urologic Association (AUA)
      • European Association of Urology (EAU)
    • Latest Information>
      • Latest News & Info
      • Latest PubMed
    • Partial Nephrectomy>
      • Partial Nephrectomy vs Radical Nephrectomy
      • Partial Nephrectomy vs Cryo-Ablation
      • Partial Nephrectomy vs RF Thermal Ablation
      • Partial Nephrectomy - Step-by-Step Videos
      • Partial Nephrectomy Prevalence in the US
      • Sliding Clip Renorrhaphy
    • Patient Survival>
      • Cardiovascular Disease by eGFR
      • Patient Mortality by eGFR
      • Survival by Tumor Stage
    • Surgical Ablation>
      • Cryo-Ablation Therapy
      • RF Thermal Ablation
      • HIFU Ultrasound
      • Microwave Ablation
      • Laser Ablation
    • Tumor Characteristics>
      • Tumor Size & Metastasis
      • Tumor Detection
  • About Us
    • Mission Statement
    • Privacy Statement
    • Clinical References
    • Terms Of Use
    • Contact Us

Rate of Metastasis by Tumor Diameter

Lughezzani, et. al. presented their retrospective study of 22,204 patients via the SEER database suggesting a strong correlation among Tumor Size and the potential for Metastasis.  In the study population the Synchronous Metastasis Rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the Synchronous Metastasis Rate increased with increasing Tumor Size, (p<0.001).  Further analysis showed that Tumor Size was virtually linearly related to the Synchronous Metastasis Rate.  Stratification by histological subtype in patients treated with Nephrectomy revealed that Clear Cell Renal Cell Cancer was most frequently associated with Synchronous Metastasis.  Finally, Tumor Size was an independent predictor of Synchronous Metastasis in multivariate regression models adjusted for age, gender, histological subtype and year of diagnosis quartiles.  
Picture
Source: Lughezzani, et.al., "Tumor size is a determinant of the rate of stage T1 renal cell cancer synchronous metastasis." The Journal of Urology (2009).
© 2014 ILoveMyKidney.org | Privacy Statement | Terms of Use | References | Contact Us